Module 12: Diseases of the Immune System
Section outline
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As a professional in allied health, you will most likely encounter in the future some patients that suffer from hypersensitivities, or autoimmune disorders, or immunodeficiencies, or suffer from cancer. Understanding the theoretical framework of these conditions will not only allow you to understand prophylactic treatment or therapeutic treatment. It will also empower you to be a more informed advocate for the patient and liaison between patient and doctors. The textbook chapter, the lecture slides, and quiz will allow you to acquire knowledge and assess your knowledge. Some information about the situation of multiple sclerosis in Louisiana and local research will be given.
.Image: Foods that can cause allergic reactions, including eggs, milk, nuts, and wheat. Source: "Food Allergy: Eggs, Milk, Nuts, and Wheat" by NIAIDis licensed
Upon completion of this module, you will be able to:
- Obj.
1 Identify and compare the distinguishing
characteristics, mechanisms, and major examples of type I, II, III, and IV
hypersensitivities (C.O.
#2 Explain the immune system, including defenses of
the host and immune diseases.)
- Obj. 2 Explain why autoimmune disorders develop (C.O. # 2)
- Obj.
3 Provide a few examples of organ-specific and systemic
autoimmune diseases (C.O.
# 2)
- Obj.
4 Explain why human leukocyte antigens (HLAs) are
important in tissue transplantation
(C.O. # 2)
- Obj.
5 Explain the types of grafts possible and their
potential for interaction with the immune system (C.O. #2)
- Obj.
6 Describe what occurs during graft-versus-host disease
(GVHD)
(C.O. #2)
- Obj.
7 Compare the causes of primary and secondary
immunodeficiencies (C.O.
#2)
- Obj.
8 Describe treatments for primary and secondary
immunodeficiencies
(C.O. #2)
- Obj.
9 Explain how the adaptive specific immune response
responds to tumors
(C.O. #2)
- Obj.
10 Discuss the risks and benefits of tumor vaccines (C.O. #2)
To achieve these objectives:
[Edit these items to match your resources and activities.]
- Read the Module 12 Introduction
- Read Read Chapter 12 in Medical Microbiology for Nursing and Allied Health: A Louisiana Perspective
- Complete reading the lecture slides about immune diseases and take the quiz about immune disorders . Complete the assignment Module #12 Assignment PubMed Central article about risk and benefit of tumor vaccines .
Module Pressbooks Resources and Activities
You will find the following resources and activities in this module at the Pressbooks website. Click on the links below to access or complete each item.
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Students mustMark as done
Motivation:
This assignment addresses course outcome (C.O. #2 Explain the immune system, including defenses of the host and immune diseases.) and module learning objective # 10 Discuss the risks and benefits of tumor vaccines. It also addresses digital literacy by using a professional search engine. It also familiarizes you as allied health professionals to find peer-reviewed scientific information, so that you can learn more about health topics and be an advocate for patients in regard to health topics.
Instruction:
You are supposed to find a research article on PubMed Central about tumor vaccines that contains information about some risk and some benefit of tumor vaccines. Then you upload (as file or photo of handwritten notes or type in the text field) in the assignment the following information:
1) the name of the article, 2) the name of the author(s), 3) the name of the journal, 4) volume and page number, 5) year of publication, 6) one benefit, and 7) one risk.
· Open internet browser and type in as search term “PubMed Central”
· Click the result PubMed Central – NIH . (The link is https://pmc.ncbi.nlm.nih.gov/ ).
· A website of PubMed Central opens. Type in the search bar the following text including parentheses and all the words: tumor vaccines[title] AND benefit[title/abstract] AND risk[title/abstract]
· If you can’t find an article with these terms then you can use the following terms: cancer vaccines[title] AND benefit[title/abstract] AND risk[title/abstract]
· You noticed the word AND is capitalized on purpose to combine search terms. Square parenthesis [] instead of round parenthesis () is used.
· This search resulted in 44 articles, but not all are about tumor vaccines; article number 9 was the article I am using as an example for this assignment. You need to pick a different article than the article given as an example.
· You need to open or download the article and find the information about the benefit and the risk listed within the article (Your browser or PDF reader may have a search function. You can enter as a search term “benefit” or “risk” and find what the article says about that.
Example
1) the name of the article:
Comparative Efficacy of Immune Checkpoint Inhibitors and Therapeutic Vaccines in Solid Tumors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
2) the name of the author(s): Babiker R, Wali AF, El-Tanani M, Rabbani SA, Rangraze I, Satyam SM, Patni MA, El-Tanani Y.
3) the name of the journal: Vaccines (Basel).
4) volume and page number: 13(4):423.
5) year of publication: 2025
6) one benefit: Immune checkpoint inhibitors (ICI)s showed a statistically significant overall survival (OS) benefit
7) one risk: Variations in gut flora that impact host immunity could play a role in the risk of these events
Evaluation rubric or grading rubric
name of the article
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
name of the author(s)
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
name of the journal
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
volume and page number
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
year of publication
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
one benefit
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
one risk
Correct :14.3 points
Incorrect : 7 points
Missing : 0 points
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Please download and read lecture slides about immune diseases
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Dear students,
please use the H5P activity about immune disorders to assess your understanding of concepts.
- Obj.
1 Identify and compare the distinguishing
characteristics, mechanisms, and major examples of type I, II, III, and IV
hypersensitivities (C.O.
#2 Explain the immune system, including defenses of
the host and immune diseases.)
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